By Andreas Offenhäusser, Ross Rinaldi
The assorted elements of bioelectronics reviewed during this booklet emphasize the gigantic advancements within the box of bioelectronics and nano-bioelectronics. the variety of topics addressed emphasize key features and the long run views of nano-bioelectronics. The booklet discusses the digital coupling of DNA and proteins with digital units to construct new info structures and to use the structures as biosensors. The exploitation of networks of neurons hooked up with digital units in destiny details processing platforms and using nano-objects to evaluate mobile functionality is usually mentioned intimately. a number of the subject matters addressed during this ebook can be of curiosity to physicists, chemists, biologists, fabric scientists and engineers, in addition to allure younger researchers and introduce them to the sector with a massive number of literature references.
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Additional info for Nanobioelectronics - for Electronics, Biology, and Medicine
These effects, originating from short-range duplex–duplex interactions, are independent of DNA base sequences and should be universal for any type of nanostructured probe that is heavily functionalized with oligonucleotides (Jin et al. 2003; Long and Schatz 2003). The three-dimensional assembly techniques via DNA hybridization introduced by Mirkin and co-workers led to one major field of application of gold nanoparticles: the diagnostics of nucleic acids (Storhoff and Mirkin 1999). Many excellent review articles are available summarizing this field of application (Mirkin 2000; Shipway et al.
38(12), 1808–1812. Angew. Chem. 111(12), 1925–1929. J. E. (2001). DNAdirected assembly of gold nanowires on complementary surfaces. Adv. Mater. 13(4), 249–254. A. (2000). Programming the assembly of two- and three-dimensional architectures with DNA and nanoscale inorganic building blocks. Inorg. Chem. 39(11), 2258–2272. C. J. (1996). A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382(6592), 607–609. A. L. (1999). Programmed assembly of DNA-functionalized quantum dots.
In a last step a biotin functionalized nanoparticle could be bound to the strepatavidin function and thus localized in the gap structure. The individual steps of the device fabrication were monitored by means of TEM and are shown in Figs. 1-17A to D. Reports of the electrical characterization of one-dimensional DNA templated nanostructures have been published (Ford et al. 2001; Richter et al. 2001; Seidel et al. 2004). These wires all showed ohmic behavior in the I–V characteristics. No quantum size effects could be observed in the electrical transport properties as all these structures were densely metallized or further developed by means of electroless plating.