Meningococcal Disease: Methods and Protocols by Keith Cartwright (auth.), John M. Walker, Andrew J. Pollard

By Keith Cartwright (auth.), John M. Walker, Andrew J. Pollard MD, PhD, Martin C. J. Maiden PhD (eds.)

Neisseria meningitidis is a tremendous reason behind adolescence morbidity and mortality in industrialized international locations and is liable for epidemics of meningococcal meningitis and septic surprise in Africa and Asia. In Meningococcal ailment: tools and Protocols, Andrew Pollard and Martin Maiden assemble a panel of top experts to supply a entire, interdisciplinary survey of modern advances and information approximately this much-feared sickness. The evaluate and methods-based chapters accrued the following supply crucial details for analysis within the medical microbiology laboratory, isolate characterization, scientific administration, and regulate of meningococcal affliction. additionally they learn the immunopathological mechanisms taking place within the acutely unwell, host-pathogen interactions, and the prospective elements of meningococcus chargeable for virulence. A better half quantity, Meningococcal Vaccines, presents designated equipment for the layout and overview of meningococcal vaccines.
finished and authoritative, Meningococcal sickness: equipment and Protocols integrates the elemental technology and the medical and epidemiological facets of this bad infectious ailment to advertise the deeper knowing had to determine novel pursuits for healing interventions and vaccines.

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Consider direct inoculation for antibiotic sensitivity testing e. Consider optochine test (on blood-agar medium) when suspecting pneumococci Consider antigen detection Consider DNA detection sistent suspicion of meningococcal disease. Some of these methods are described in other chapters of this book and comprise antigen-detection methods including latex- and co-agglutination techniques (10); direct immunofluorescence with specific conjugates (3,10); enzyme immunoassays (34,35); and DNA amplification methods like PCR for different target sequences like the 16S rRNA gene (36–38) and the ctrA gene.

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