By Novartis Foundation(eds.)
This fascinating publication brings jointly a world and interdisciplinary workforce of specialists to debate the significance of pulsatile signalling within the induction of organic responses. assurance comprises the elemental mechanisms concerned with hormone pulsatility, the importance of pulsatility in common and ailment stipulations, the relevance of circadian rhythms, alterations with getting older, and particular attention of particular peptide hormone platforms. This booklet comprises contributions from execs operating in either easy and scientific study and divulges a lot new and interesting paintings during this region and delivers new study directions.Content:
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Additional resources for Mechanisms and Biological Significance of Pulsatile Hormone Secretion: Novartis Foundation Symposium 227
Di¡erent types of physiological response may correspond to di¡erent optimal frequencies of a given pulsatile signal in the same or in di¡erent types of target cells. The role of the frequency of the physiological rhythm extends beyond the case of pulsatile signals. Thus, intracellular Ca2+ oscillations occur in many cell types in response to extracellular signals which need not be themselves of a pulsatile nature. As shown above, these signals can be transduced via Ca2+ spikes into frequency-dependent intracellular responses.
Shown in Fig. 7 are three phosphorylation curves corresponding to the same kinase coupled to three di¡erent phosphatases characterized by di¡erent maximum rates. The results indicate that in such conditions the same frequency of Ca2+ oscillations can be transduced into three di¡erent levels of phosphorylated target proteins, which in turn induce various levels of activation of Ca2+-mediated responses involving the same kinases. This kind of e¡ect can also allow the pattern of Ca2+ oscillations (rates of rise and decline, half-width) to modulate the nature of the cellular response.
Goldbeter: We have not considered non-linear functions, nor have we considered the interesting aspect of the rate of transition between the receptor states. The reason why we focused on the linear combination of receptor states is that we made the simplest assumption that it is the amounts of complexes between the ligand and the receptor in its various states that brings about the physiological response. It would be interesting to compare the predictions of this model with your alternative approach.