By Jack L. Chalker
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Scaffolds are currently being designed as tissue regenerative implants for damaged brain tissue. , 2008). What essential properties do scaffolds in brain tissue engineering need to meet? • Scaffolds must be biocompatible, biodegradable, and small enough to infiltrate cells and release drugs in a controlled manner. • Scaffolds must also preserve the integrity of the BBB. • Scaffolds must be porous, and have optimal pore dimensions and surface functionality, and must support neural cells. • Scaffolds must not elicit host immune system reactions.
Biomaterials 27, 519À533. , 2012. Schwann cell transplantation: a repair strategy for spinal cord injury? Prog. Brain Res. 201, 295À312. , 2013. Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurological function in a rat model of middle cerebral artery occlusion. Stem Cell Res. Ther. 4, 73. CHAPTER 5 Ophthalmic Tissue Engineering F. 1 INTRODUCTION There are approximately 285 million people worldwide who are visually impaired (WHO, 2014).
2000. Schwann-like macroglia in adult rat brain. Glia 30, 49À63. , 2005. The repair of brain lesion by implantation of hyaluronic acid hydrogels modified with laminin. J. Neurosci. Methods 148 (1), 60À70. , 2014. Overcoming short gaps in peripheral nerve repair: conduits and human acellular nerve allograft. Hand 9, 131À137. , 2014. Tissue engineering is a promising method for the repair of spinal cord injuries. Exp. Therap. Med. 7 (3), 523À528. , 2010. Mesenchymal stem cells for the treatment of neurodegenerative disease.