By Jean-Pierre Marie, Ollivier Legrand (auth.), G. J. L. Kaspers, R. Pieters, A. J. P. Veerman (eds.)
Cellular drug resistance is an immense quandary to the luck of chemotherapy of leu kemia and lymphoma. the significance of this has now been well-known by way of either clinicians and scientists. it really is of maximum significance to bridge the space among laboratory and sanatorium during this box of study. this is often the most goal of the sequence of foreign Symposia on Drug Resistance in Leukemia and Lymphoma. those are held each 3 years in Am sterdam, The Netherlands, for the reason that 1992. This booklet includes the lawsuits of the 3rd of those conferences, organised in 1998. The ebook covers all very important features of drug resistance in leukemia and lymphoma, either within the type of wide studies as in manuscripts describing unique information. common mechanisms of resistance are mentioned, together with the drug resistance comparable proteins p glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the position of glutathione and glutathione-S-transferases. furthermore, extra drug type-specific mechanisms of resistance are an issue, reminiscent of for glucocorticoids and antifolates. a lot in formation is supplied on apoptosis and its regulators, and at the result of telephone tradition drug resistance assays. a number of papers concentrate on the modulation or circumvention of drug resistance.
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