Drug Resistance in Leukemia and Lymphoma III by Jean-Pierre Marie, Ollivier Legrand (auth.), G. J. L.

By Jean-Pierre Marie, Ollivier Legrand (auth.), G. J. L. Kaspers, R. Pieters, A. J. P. Veerman (eds.)

Cellular drug resistance is an immense quandary to the luck of chemotherapy of leu­ kemia and lymphoma. the significance of this has now been well-known by way of either clinicians and scientists. it really is of maximum significance to bridge the space among laboratory and sanatorium during this box of study. this is often the most goal of the sequence of foreign Symposia on Drug Resistance in Leukemia and Lymphoma. those are held each 3 years in Am­ sterdam, The Netherlands, for the reason that 1992. This booklet includes the lawsuits of the 3rd of those conferences, organised in 1998. The ebook covers all very important features of drug resistance in leukemia and lymphoma, either within the type of wide studies as in manuscripts describing unique information. common mechanisms of resistance are mentioned, together with the drug resistance comparable proteins p­ glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the position of glutathione and glutathione-S-transferases. furthermore, extra drug type-specific mechanisms of resistance are an issue, reminiscent of for glucocorticoids and antifolates. a lot in­ formation is supplied on apoptosis and its regulators, and at the result of telephone tradition drug resistance assays. a number of papers concentrate on the modulation or circumvention of drug resistance.

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Mizuno Y, Hara T, Nagata M, Tawa A, Tsuruo T, Ueda K (1991) Detection of multi drug-resistant protein, P-glycoprotein in childhood leukaemia and lymphoma. Eur J Pediatr 150: 416-418 6. Ubezio P, Limonta M, D'incalci M, Damia G, Masera G, Giudici G, Wolverto J, Beck WT (1989) Failure to detect the P-glycoprotein multidrug resistant phenotype in case of resistant childhood acute lymphoblastic leukemia. Eur J Cancer Clin Oncol 25: 1895-1899 7. Pieters R, Hongo T, Loonen AH (1992) Different types ofnon-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukeamia.

Eur J Pediatr 150: 416-418 6. Ubezio P, Limonta M, D'incalci M, Damia G, Masera G, Giudici G, Wolverto J, Beck WT (1989) Failure to detect the P-glycoprotein multidrug resistant phenotype in case of resistant childhood acute lymphoblastic leukemia. Eur J Cancer Clin Oncol 25: 1895-1899 7. Pieters R, Hongo T, Loonen AH (1992) Different types ofnon-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukeamia. Br. J Cancer 65:691~97 8. Langermann H J, Henze G, Wulf M, Riehm H (1982) Abschatzung der Tumorzellmasse bei der akuten Iymphoblastischen Leukamie im Kindersalter: prognostische Bedeutung und praktische Anwendung.

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