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Additional resources for Development of a Biokinetic Model for Radionuclide-Contaminated Wounds for Their Assessment, Dosimetry and Treatment (2006) (Ncrp Report)

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This has been supported at least in part by experimental data in rats instilled with 10 μm (Oberdorster, 1993) or 15 μm particles (Snipes and Clem, 1981), in which there was virtually no clearance of particles from the lung. Additionally, Mueller et al. (1990) showed that the migration in vitro of rat and dog alveolar macrophages decreased with increasing numbers of ingested particles, and ceased at high particle loadings. It is not known whether this mechanism also applies to interstitial macrophages, but it is logical to assume that it does, since the mechanism is probably linked both to energy consumption by the macrophage, which would not be specific to the different macrophage types, and to the inability of macrophages loaded with solid particles to move through tight spaces.

The uptake of activity into the systemic circulation from a wound site is highly variable, depending on the physical and chemical form of the radionuclide, the depth of the wound and extent of tissue injury, the treatment given, and the time elapsed between injury and treatment. For example, the effectiveness of wound excision varies with the depth of the wound and the time elapsed since the injury, but for most wounds, excision (often repeated) can remove >90 % of the initial activity from the wound site (Ilyin, 2001).

For example, the effectiveness of wound excision varies with the depth of the wound and the time elapsed since the injury, but for most wounds, excision (often repeated) can remove >90 % of the initial activity from the wound site (Ilyin, 2001). , nitrates) of these 24 / 3. ETIOLOGY OF RADIONUCLIDE-CONTAMINATED WOUNDS radionuclides from the body, but is essentially ineffective in removing less-soluble forms such as oxides (Ilyin, 2001). Because of these interventions, which may drastically alter the local and systemic biokinetics of radionuclides in a wound, there are few human case reports in the literature that can be used to develop a biokinetic model for contaminated wounds.

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