Computational Biomechanics for Medicine: Fundamental Science by Barry Doyle, Karol Miller, Adam Wittek, Poul M.F. Nielsen

By Barry Doyle, Karol Miller, Adam Wittek, Poul M.F. Nielsen

One of the best demanding situations dealing with the computational engineering group is to increase the luck of computational mechanics to fields open air conventional engineering, particularly to biology, the biomedical sciences and medication. The Computational Biomechanics for Medicine sequence presents a chance for experts in computational biomechanics to offer their newest methodologies and developments. This fifth variation includes 9 of the most recent advancements in either basic technological know-how and patient-specific purposes, from researchers in Australia, New Zealand, united states, united kingdom, France, eire and China. many of the attention-grabbing subject matters mentioned are: mobile mechanics; tumor progress and modeling; clinical snapshot research and either patient-specific fluid dynamics and reliable mechanics simulations.

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Kansal A, Torquato S, Harsh G, Chiocca E, Deisboeck T (2000) Simulated brain tumor growth dynamics using a three-dimensional cellular automaton. J Theoret Biol 203(4):367–382 8. Sciumè G (2013) A multiphase model for three-dimensional tumor growth. New J Phys 15(1):015005 9. Frieboes HB, Jin F, Chuang Y-L, Wise SM, Lowengrub JS, Cristini V (2010) Threedimensional multispecies nonlinear tumor growth—II: tumor invasion and angiogenesis. J Theoret Biol 264(4):1254–1278 10. Potts RB (1952) Some generalized order–disorder transformations.

The location of these focal lesions has been found to correlate with regions of low wall shear stress (WSS) [2]. Recent prospective studies using IVUS and VH-IVUS have supported these observational findings. WSS has been found to be an independent predictor of increased plaque burden [3]. Further, arterial segments exposed to low WSS see an increase in plaque progression [4] and in necrotic core content [5]. A number of recent IVUS-based studies have compared absolute values of WSS with plaque progression and plaque thickness [4, 6], though these studies appear to have neglected the presence of side-branches.

Fujimoto J, Ichigo S, Hirose R, Sakaguchi H, Tamaya T (1998) Expressions of vascular endothelial growth factor (VEGF) and its mRNA in uterine endometrial cancers. Cancer Lett 134(1):15–22 4. Makrilia N, Lappa T, Xyla V, Nikolaidis I, Syrigos K (2009) The role of angiogenesis in solid tumours: an overview. Eur J Intern Med 20(7):663–671 5. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674 6. Araujo R (2004) A history of the study of solid tumour growth: the contribution of mathematical modelling.

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