Biomedical Applications of Peptide-, Glyco- and Glycopeptide by Jaroslav Sebestik, Milan Reinis, Jan Jezek

By Jaroslav Sebestik, Milan Reinis, Jan Jezek

Dendrimers are time and again branched and approximately round huge molecules. they are often utilized in quite a few clinical purposes, equivalent to anticancer polymeric nanomedicines and nanocarriers, gene providers and vectors in gene supply, distinction brokers for molecular imaging and vaccines opposed to infectious illnesses and melanoma. The hugely branched, multivalent nature and molecular structure of dendrimers lead them to excellent instruments for quite a few tissue engineering purposes. This publication describes varied different types of dendrimers, their biomedical and physico-chemical purposes in addition to convergent and divergent syntheses, click on chemistry and ligation thoughts. it's a wealthy resource of data for researchers in biochemistry and pharmacology engaged on drug improvement in addition to for natural chemists who're engaged in synthesis of dendrimers.

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J. Am. Chem. Soc. 131(49), 17765–17767 (2009) References 19 69. : Synthesis and properties of first and second generation chiral dendrimers with triply branched units: A spectacular case of diastereoselectivity. Helv. Chim. Acta. 80(5), 1648–1681 (1997) 70. : Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands. ChemBioChem. 3(9), 836–844 (2002) 71. : Remarkably size-regulated cell invasion by artificial viruses. Saccharide-dependent self-aggregation of glycoviruses and its consequences in glycoviral gene delivery.

Identification of a dendrimeric heparan sulfate-binding peptide that inhibits infectivity of genital types of human papillomaviruses. Antimicrob. Agents Chemother. 54(10), 4290–4299 (2010) 42. : Oligomannoside mimetics by glycosylation of “octopus glycosides” and their investigation as inhibitors of type 1 fimbriae-mediated adhesion of Escherichia coli. Org. Biomol. Chem. 4(21), 3901–3912 (2006) 43. : Glyco-nanomaterials: Translating insights from the “sugar-code” to biomedical applications. Curr.

Glyco-nanomaterials: Translating insights from the “sugar-code” to biomedical applications. Curr. Med. Chem. 18(14), 2060–2078 (2011) 7. : Fats and factors: lipid profiles associate with personality factors and suicidal history in bipolar subjects. PLoS ONE 7(1), Art. No. e29,297 (2012) 8. : Carbohydrates and glycoconjugates. Glycomics: the new era of carbohydrate biology. Curr. Opin. Struct. Biol. 13(5), 602–604 (2003) 9. : Lipids plus genomics equals lipomics. Scientist 16(3), 42–42 (2002) 10.

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