Behavioral Neurobiology of Bipolar Disorder and its by Husseini K. Manji, Carlos A. Zarate Jr.

By Husseini K. Manji, Carlos A. Zarate Jr.

This ebook bargains the main updated information regarding learn surrounding the neurobiology of bipolar ailment in addition to at present to be had and novel healing techniques. the quantity has assembled a greatly revered team of preclinical and scientific researchers who carry their services to undergo upon this affliction through reviewing state-of-the-art learn and scientific proof in regards to the pathophysiology and remedy of bipolar affliction. Early chapters overview the path and final result and genetics of this hugely heritable situation, together with chapters on epigenetics and scientific endophenotypes. a number of chapters provide a remarkably thorough and distinctive evaluation of the neurobiology of the disease, together with what's recognized from neuroimaging paintings and the advance of animal versions. ultimately, the ebook covers therapy ideas for bipolar ailment, together with either conventional and novel therapeutics, in addition to non-pharmacological remedies. It bargains either researchers and clinicians key insights into this devastating ailment.

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Extra info for Behavioral Neurobiology of Bipolar Disorder and its Treatment (Current Topics in Behavioral Neurosciences, Volume 5)

Example text

32 Concepts in Epigenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 Bipolar Disorder: The Epigenetic Perspective . . . . . . . . . . . . . . . . . . . . . . 34 Discordance of Monozygotic Twins . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Sexual Dimorphism . . . . . . . . . . . . . . . . . . . . . . . . . . . .

35 Sexual Dimorphism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 Parent of Origin Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Other Epigenetic Effects That May Be of Relevance to BPD . . . . . . . . . . . . . . 38 Experimental Approaches to Epigenetic and Epigenomic Studies of BPD . . . . . . . 40 Pilot DNA Methylome Study in BPD .

22 4 New Strategies in BPD Genetics Research . . . . . . . . . . . . . . . . . . . . . . . 1 Redefining the Phenotype . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Novel Molecular Tools . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Novel Analytical Tools . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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