Anthracycline Chemistry and Biology II: Mode of Action, by Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn

By Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn (eds.)

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The number of true “analogs” keeps growing year after year. In returning to comparisons of DOX with EPI, we will focus on those analogues that proved to form fewer amounts of ROS and/or secondary alcohol metabolite; this will serve as an opportunity to verify whether the free radical or alcohol metabolite hypotheses of cardiotoxicity translated into chemical entities more advantageous than EPI. Attempts to eliminate an involvement of DOXOL in cardiotoxicity formed the rationale to design C-13 deoxydoxorubicin (Fig.

Kaiserová H, Simunek T, Sterba M, den Hartog GJ, Schröterová L, Popelová O, Gersl V, Kvasnicková E, Bast A (2007) Cardiovasc Toxicol 7:145 55. Anderlini P, Benjamin RS, Wong FC, Kantarjian HM, Andreeff M, Kornblau SM, O’Brien S, Mackay B, Ewer MS, Pierce SA (1995) J Clin Oncol 13:2827 56. Crivellari D, Lombardi D, Corona G, Massacesi C, Talamini R, Sorio R, Magri MD, Lestuzzi C, Lucenti A, Veronesi A, Toffoli G (2006) Ann Oncol 17:807 57. Toffoli G, Sorio R, Basso B, Aita P, Corona G, Ruolo G, Boiocchi M (2004) J Chemother 16:193 58.

One-Electron Oxidative Degradation and Detoxification . . . . . . . . . . . . . . . . . . . . . . 4 Translating the Metabolic Determinants of Cardiotoxicity into Protective Strategies Antioxidants . . . . . . . . . Iron Chelators . . . . . . . . Noncardiotoxic Anthracycline Analogs . Modulators of Anthracycline Degradation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Cardiotoxic Synergism of Anthracyclines with Other Drugs .

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